Publications & Presentations

Sumitomo Dainippon Pharma Oncology conducts extensive scientific and clinical research to support its diverse pipeline. Learn more about ongoing initiatives from the publications, abstracts, and presentations below.

Publications

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Vaccine therapies for cancer: then and now

Morse M, Gwin III W, Mitchell D.

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TP-0903 is active in models of drug-resistant acute myeloid leukemia

Jeon JY, Buelow DR, Garrison DA, et al.

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Phase 1 study of alvocidib followed by 7+3 (cytarabine + daunorubicin) in newly diagnosed acute myeloid leukemia

Zeidner JF, Lee DJ, Frattini M, et al.

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Cyclin-dependent kinase (CDK) 9 and 4/6 inhibitors in acute myeloid leukemia (AML): a promising therapeutic approach

Lee DJ, Zeidner JF.

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Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy

Kadia TM, Kantarjian HM, Konopleva M.

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A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease

Litzow MR, Wang XV, Carroll MP, et al.

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Current and emerging therapies for patients with acute myeloid leukemia: a focus on MCL-1 and the CDK9 pathway

Lyle L, Daver N.

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Final results of a randomized multicenter phase II study of alvocidib, cytarabine, and mitoxantrone versus cytarabine and daunorubicin (7 + 3) in newly diagnosed high-risk acute myeloid leukemia (AML)

Zeidner JF, Foster MC, Blackford AL, et al.

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Exposure-response analysis of alvocidib (flavopiridol) treatment by bolus or hybrid administration in newly diagnosed or relapsed/refractory acute leukemia patients

LaCerte C, Ivaturi V, Gobburu J, et al.

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Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo

Zhou L, Zhang Y, Sampath D, et al.

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Combined venetoclax and alvocidib in acute myeloid leukemia

Bogenberger J, Whatcott C, Hansen N, et al.

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Chronic lymphocytic leukemia cells from ibrutinib treated patients are sensitive to Axl receptor tyrosine kinase inhibitor therapy

Sinha S, Boysen JC, Chaffee KG, et al.

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TP-0903 inhibits neuroblastoma cell growth and enhances the sensitivity to conventional chemotherapy

Aveic S, Corallo D, Porcù E, et al.

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PIM1 (Moloney murine leukemia provirus integration site) inhibition decreases the nonhomologous end-joining DNA damage repair signaling pathway in pulmonary hypertension

Lampron MC, Vitry G, Nadeau V, et al.

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TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells

Whillock AL, Mambetsariev N, Lin WW, Stunz LL, Bishop GA.

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Recent Abstracts and Presentations

2021 AACR Virtual Annual Meeting
  • PKM2 activation modulates the tumor-immune microenvironment and enhances response to checkpoint inhibitors in preclinical solid tumor models (Abstract) (Poster)
  • Pharmacodynamic biomarkers for Pim inhibition with TP-3654 in patients with solid tumors (Abstract) (Poster)
  • TP-5809, a novel TNK1 inhibitor, suppresses TNK1 dependent signaling and tumor growth in a preclinical model of Hodgkin’s lymphoma (Abstract) (Poster)
  • CDK9 inhibition combined with hypomethylating agents target MCL-1 dependency in MDS and AML (Abstract) (Poster)
2020 ASH Virtual Congress
  • A phase 1 study of TP-3654, an orally-delivered PIM kinase inhibitor, in patients with intermediate-2 or high-risk primary or secondary myelofibrosis (Abstract) (Presentation)
2020 ESMO Virtual Congress
  • Phase 1, first-in-human, safety, pharmacokinetic and pharmacodynamic study of oral dubermatinib (TP‑0903) in patients with advanced solid tumors (Abstract)
2020 ASCO Virtual Scientific Program
  • A phase I, first-in-human, open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of oral TP-1287 administered daily to patients with advanced solid tumors (Abstract)
  • A phase I, first-in-human, open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of oral TP-3654 administered daily for 28 Days to patients with advanced solid tumors (Abstract)
  • A phase 1b/2, multicenter, open-label study of DSP-7888 dosing emulsion in combination with immune checkpoint inhibitors (CPI) nivolumab or pembrolizumab in adult patients (pts) with advanced solid tumors, including platinum-resistant ovarian cancer (PROC) (Abstract)
2020 EHA Virtual Annual Meeting
  • Zella-101: phase 1 study of alvocidib followed by 7+3 induction in newly diagnosed AML (Abstract)
2020 AACR Virtual Annual Meeting
  • Pharmacodynamic biomarker strategies for CDK9 inhibition
2019 SITC Annual Meeting, National Harbor, MD
  • Multicenter, open-label, phase 1 study of DSP-7888 dosing emulsion (DSP-7888) in patients with advanced malignancies (Abstract)
  • A first-in-human, phase 1, multicenter trial of toll-like receptor (TLR) 7 agonist DSP-0509 as monotherapy and in combination with pembrolizumab in adult patients with advanced solid tumors (Abstract)
2018 ASCO Annual Meeting, Chicago, IL
  • A randomized, multicenter phase 2 study of DSP-7888 dosing emulsion in combination with bevacizumab (Bev) versus Bev alone in patients with recurrent or progressive glioblastoma (Abstract)

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